Clinical Research

Analgesic Research

Dr Stuart Ratcliffe, a leader in the scientific design and conduct of analgesic trials, heads the Pain Research division at MAC (UK) Neuroscience. By using MAC UK's proven recruitment methodologies, together with innovative psychological and psychophysical approaches in patient selection we are able to improve the efficiency and reduce cycle times in early drug development. As well as traditional Phase IIb and Phase III trials MAC UK has an impressive and expanding track record in the performance of key 'go, no-go' Phase IIa trials.

Existing databases of potential trial subjects include patients with pain due to, amongst others:

• osteoarthritis
• diabetic neuropathy
• post-herpetic neuralgia
• post-surgical and post-trauma neuropathy
• and multiple sclerosis

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Cognitive Research

From the early success of the currently licensed cholinesterase drugs such as Aricept, MAC has been involved in the continuing development of new treatments for Alzheimer's Disease, including Phase 1-3 trials with monoclonal antibodies. Outcome measure assessments available through MAC include computerised test batteries, fMRI and Amyloid PET as outcome measures. 
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